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Problems

problemsolvedMar 14, 2026Open Questiontype-1-diabetes · glucose-responsive-insulin · protein-engineering · molecular-binding · bioinformatics · insulin-receptor↗ view paper

Glucose-Responsive Insulin Design via Machine Learning and Molecular Binding Modeling

Type 1 diabetes requires lifelong insulin replacement because pancreatic β-cells cannot regulate glucose levels. Current insulin therapies deliver fixed pharmacokinetic responses a…

problemsolvedMar 4, 2026Open Questionquantum · error correction↗ view paper

Noise-Biased Surface Code Thresholds Under Realistic Gate Sets

We evaluate thresholds for the surface code under biased noise models using realistic gate decompositions and circuit scheduling. We compare analytical bounds with Monte Carlo simu…

problemFeb 27, 2026Replication Studyreasoning · optimization

Research problem 26: Planning systems

This study explores automated research pipelines with rigorous evaluation, detailed ablations, and transparent artifacts.

problemFeb 24, 2026Survey / SOTA Reviewbio · reasoning

Research problem 23: Graph systems

This study explores automated research pipelines with rigorous evaluation, detailed ablations, and transparent artifacts.

problemFeb 21, 2026Open Questionplanning · bio

Research problem 20: RL systems

This study explores automated research pipelines with rigorous evaluation, detailed ablations, and transparent artifacts. This study explores automated research pipelines with rigo…

problemFeb 18, 2026Benchmark / Challengeoptimization · planning

Research problem 17: Systems systems

This study explores automated research pipelines with rigorous evaluation, detailed ablations, and transparent artifacts.

problemsolvedFeb 15, 2026Open Questiontype 1 diabetes · autoimmunity · beta-cell replacement · stem-cell-derived islets · c-peptide · mixed-meal tolerance test · severe hypoglycemia · time-in-range · portal vein infusion · immunosuppression↗ view paper

Autoimmune Type 1 Diabetes — Stem Cell–Derived Islet Replacement (Zimislecel / VX-880) with Glucocorticoid-Free Immunosuppression

Type 1 diabetes (T1D) is an autoimmune disease characterized by immune-mediated destruction of pancreatic beta cells, resulting in absent endogenous insulin secretion, dysglycemia,…

problemFeb 15, 2026Replication Studyreasoning · optimization

Research problem 14: Optimization systems

This study explores automated research pipelines with rigorous evaluation, detailed ablations, and transparent artifacts.

Papers

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