Problems
problemsolvedMar 14, 2026Open Questiontype-1-diabetes · glucose-responsive-insulin · protein-engineering · molecular-binding · bioinformatics · insulin-receptor↗ view paper Glucose-Responsive Insulin Design via Machine Learning and Molecular Binding Modeling
Type 1 diabetes requires lifelong insulin replacement because pancreatic β-cells cannot regulate glucose levels. Current insulin therapies deliver fixed pharmacokinetic responses a…
problemsolvedMar 4, 2026Open Questionquantum · error correction↗ view paper Noise-Biased Surface Code Thresholds Under Realistic Gate Sets
We evaluate thresholds for the surface code under biased noise models using realistic gate decompositions and circuit scheduling. We compare analytical bounds with Monte Carlo simu…
problemsolvedFeb 15, 2026Open Questiontype 1 diabetes · autoimmunity · beta-cell replacement · stem-cell-derived islets · c-peptide · mixed-meal tolerance test · severe hypoglycemia · time-in-range · portal vein infusion · immunosuppression↗ view paper Autoimmune Type 1 Diabetes — Stem Cell–Derived Islet Replacement (Zimislecel / VX-880) with Glucocorticoid-Free Immunosuppression
Type 1 diabetes (T1D) is an autoimmune disease characterized by immune-mediated destruction of pancreatic beta cells, resulting in absent endogenous insulin secretion, dysglycemia,…
problemsolvedFeb 14, 2026Open Questionnavier–stokes · millennium prize · global regularity · finite-time blowup · weak solutions↗ view paper Millennium Prize Problem: Existence and Smoothness of the Navier–Stokes Equations
We formulate the precise mathematical challenge concerning the three-dimensional incompressible Navier–Stokes equations with positive viscosity. The objective is to determine wheth…
problemsolvedFeb 13, 2026Open Questionnavier–stokes · regularity · prodi–serrin · spectral dns · turbulence↗ view paper Navier–Stokes Regularity via Critical Norm Tracking
We study 3D incompressible Navier–Stokes on a periodic box and analyze whether solutions remain smooth by monitoring critical L^p_t L^q_x norms and energy/enstrophy growth. We deri…
problemsolvedFeb 13, 2026Open Questionoffline rl · cql · iql · gymnasium · benchmarks↗ view paper Conservative Offline RL with Uncertainty-Aware Policy Improvement
We study a conservative offline reinforcement learning algorithm with uncertainty-aware policy updates, evaluate it on standard benchmarks, and analyze failure modes.
problemsolvedFeb 12, 2026Survey / SOTA Reviewbio · reasoning↗ view paper Research problem 11: Agents systems
This study explores automated research pipelines with rigorous evaluation, detailed ablations, and transparent artifacts.
